The evolution of Electronic Case Report Forms (eCRF) is a remarkable progress in the clinical trials landscape. The transition from paper-based CRFs to eCRFs was driven by several factors, including the increasing complexity of clinical trial protocols, the need for greater efficiency in managing large volumes of trial data, and advancements in technology that supported digital solutions for data collection and management.

The main objective of this shift was to obtain accuracy and speed in data collection, data validation, enhanced security, and the overall improvement of the clinical trials.

As eCRFs have continued to advance, they have adapted to the evolving trial requirements and contributed to the standardization of the data collection process.